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ქირალური ანტიმიკოტიკური პრეპარატების ენანტიომერების დაყოფა პოლისაქარიდული ტიპის ქირალურ სტაციონალურ ფაზებზე და პოლარულ-როგანული მობილური ფაზებით ელუირების რიგის ცვლილება

ავტორი: ალექსანდრე დადიანიძე
საკვანძო სიტყვები: ქირალური ანტიმიკოტიკური პრეპარატი

The separation of enantiomers of 10 chiral antimycotic drugs was studied on polysaccharide-based chiral columns with polar organic mobile phases. The emphasis was placed on some interesting examples of enantiomer elution order (EEO) reversal observed depending on the chemistry of the chiral selector, separation temperature, major component, as well as the minor additive to the mobile phase. In particular, it was found that the elution order of enantiomers of chiral drug terconazole was opposite on cellulose- and amylose-based columns with the same pendant group. The affinity pattern of enantiomers of another chiral drug bifonazole was opposite towards to two amylose-based chiral selectors with different pendant groups. The affinity pattern of terconazole enantiomers also changed on some columns when the alcohol-based mobile phase was replaced with acetonitrile. An interesting effect of the minor acidic (formic acid) additives to the mobile phase on the affinity pattern of terconazole enantiomers was observed on Cellulose-2 and Cellulose-4 columns. In addition, a reversal of elution order of bifonazole enantiomers was observed on Amylose-2 column by changing a separation temperature.

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