Chiral separation of imidazole and triazole derivatives using capillary electrophoresis technique

Author: Ann Gogolashvili
Co-authors: Lali Tchankvetadze
Keywords: Capillary Electrophoresis, Chirality, Enantiomer separation
Annotation:

Enantiomeric Separation of some chiral pharmaceuticals containing the imidazole and triazole were carried out using capillary electrophoresis. Various native cyclodextrins (α-, β- and γ-cyclodextrin) and derivatized cyclodextrins (heptakis-(2,6-O-dimethyl)-beta-CD, and heptakis(2,3,6-O-trimethyl)-beta-CD) were used as chiral buffer modifiers. The effects of the cavity size and the structure on the chiral recognition ability were evaluated. The influence of the type and concentration of the organic modifier on the separation of enantiomers of imidazole and triazole derivatives was studied. α-cyclodextrin does not exhibit a chiral recognition ability for the imidazole derivatives studied. Heptakis-(2,6-O-dimethyl)-beta-CD, and heptakis(2,3,6-O-trimethyl)-beta-CD shows better chiral recognition ability than the native cyclodextrins. Over 90% of the ten test chiral imidazole and triazole derivatives were enantiomerically resolved using heptakis(2,3,6-O-trimethyl)-beta-CD.